|
KMID : 0368819920310030499
|
|
Journal of the Korean Neuropsychiatr Association
1992 Volume.31 No. 3 p.499 ~ p.511
|
|
|
A Study on Relationship among Negative Symptoms and Other Symptoms of Chronic Schizophrenics
|
|
Kim Cheol-Kyu
|
|
|
Abstract
|
|
|
For an approach to the pathophysiology of negative symptoms through their classification. the authors evaluated the relationship among negative symptoms. positive depressive symptoms and extrapyramidal symptoms, and the change of each symptom.
The subjects of study were 105 chronic schizophrenics who had been admitted to the Seoul National Mental Hospital from March. 1990 to December, 1990 and negative symptoms were measured by SANS. positive symptoms by SAPS. Depressive symptoms by
HDS
and
extrapyramidal symptoms by EPSRS on admission and 4 weeks later.
@ES The results were as follows:
@EN 1) There was no significant correlation between negative symptoms and previous course of illness(number of previous hospitalization. duration of previous hospitalization., duration of previous hospitalization age at onset and months since
onset) on
admission and 4 weeks later.
2) There was significant correlation between negative symptoms and depressive symptoms (P<0.01). and between negative symptoms and extrapyramidal symptoms(P<0.01). and depressive symptoms and extrapyramidal symptoms(P<0.01) showed significant
correlation only 4 weeks later.
3) Negative symptoms. positive symptoms and depressive symptoms were significantly improved after 4 weeks treatment(all P<0.01). whereas extrapyramidal symptoms were not significantly changed.
4) For the correlation of subscales. Working capacity and loss of interest of HDS. Other items of HDS rigidity of EPSRS were significantly correlated with all subscales of SANS on admission and 4 weeks later(P<0.01, or P<0.05).
5) For the change of each subscale after 4 weeks treatment, there was significant improvement in all subscales of SANS and (all P<0.01). and in insomnia. working capacity and loss of interest, and other items of HDS(P<0.01. P<0.01. P<0.05).
whereas no
in all subseales of EPSRS.
These findings suggest that there are negative symptoms due to depressive symptoms and extrapyramidal symptoms. and that improvement of negative symptoms after 4 weeks treatment is more associated with that of depressive symptoms rather than that
of
extrapyramidal symptoms.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|